American Society of Plastic Surgeons logo
Connecticut OFFICE

2 Greenwich Office Park
Suite 210
Greenwich, CT 06831
203 863-0003

Greenwich Hospital Office

77 Lafayette Place
Suite 302
Greenwich, CT 06830
203 863-0003

Hudson Valley Office

21 Reade Place

Suite 2100
Poughkeepsie, NY 12601
203 863-0003


Identification of a new high-risk gene for breast cancer

Posted Date: June 05, 2015

A novel gene – PALB2 – greatly raises the risk for breast cancer, and should be taken seriously, according to a recent study led by Dr. Marc Tischkowitz.

A recent report in the New England Journal of Medicine published by Dr. Marc Tischkowitz and colleagues demonstrates that mutations in PALB2 significantly increases a person’s risk for breast cancer, compared with the general population. The study included 362 members from 154 families carrying the PALB2 gene mutations. When the gene is functioning normally, it acts as a tumor suppressor. When mutated, growth of cancer cells is no longer inhibited. Both men and woman men who carry a mutated form of the PALB2 gene are at significantly increased risk for breast cancer, approaching the risk associated with mutations in BRCA2 genes. Read more about the study here.